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Fall 2007
A Journey Through the Digestive System
An interview with Yale University Gastroenterologist Dr. Martin H. Floch, M.D.

Welcome to the seventh edition of Probiotics: News You Can Use, a quarterly bulletin brought to you by the Dannon Probiotics Center.

Probiotics are living microorganisms that, when consumed in sufficient amounts, can provide health benefits that go beyond basic nutrition. Certain probiotic strains help strengthen your body's natural defenses by providing a regular source of "friendly" bacteria for the intestinal tract. Others can help regulate the digestive system by helping regulating the time it takes for food to pass through the intestine.

The benefits that probiotics can bring to the intestine have received a lot of media attention in recent months. Just as compelling, but less well known, is the research that indicates probiotics play a role elsewhere in the digestive system.

Martin H. Floch, M.D. is clinical professor of medicine of the Yale University Department of Internal Medicine, editor of the Journal of Clinical Gastroenterology, and the author of Netter's Gastroenterology and Diet and Nutrition Therapy in Gastroenterology. In an interview with Dannon, he discussed the way probiotics operate not only in the small and large intestine, but in the mouth, stomach, and liver.

1. Studies have indicated that certain probiotic cultures have an effect on the cavity-causing bacteria in the mouth.1 Other probiotics are being studied for their ability to reduce the bacteria that cause bad breath.2 What's your view on probiotic activity in the mouth?

There hasn't been a great deal published [compared to findings related to the intestine], but there have been some studies that indicate probiotics could play a role in the maintenance of mouth health. Although the data is scarce, what is available makes sense. If you have the probiotic organisms in your mouth, they would have an effect on the bacterial population of the mouth, including bacteria that may be responsible for cavities and bad breath.

2. What about probiotics in the stomach? Two years ago, researchers Barry Marshall and Robin Warren won the Nobel Prize for discovering that peptic ulcers are caused not by stress, but by a bacterium, Helicobacter pylori.

There's been a lot of activity in this area. Animal and human studies suggest that regular intake of certain probiotic bacteria can affect the presence and activity of H. pylori and its ability to survive5. About 50 percent of the population is infected and since this is a worl

12.16.08
The Health Impacts of Active Cultures: Probiotics

Division of Nutrition, Harvard Medical School